in charge of 负责；主管，sth. is in charge of ***.某人负责某事。 take charge of 接管，负责，***. take charge of sth.某人负责某事。
1、in charge of 负责 be responsible for=be in charge of 对...负责任,负责...。 He is in charge of the task.他对这个任务负责。
2、take charge of 是开始管理,接管的意思,是主动。 Our department has taken charge of the 我们部门已经接管了这个任务。
